Redox-Mediated Regulatory Mechanisms of Endoplasmic Reticulum Homeostasis
نویسندگان
چکیده
منابع مشابه
Ero1 and redox homeostasis in the endoplasmic reticulum.
Living cells must be able to respond to physiological and environmental fluctuations that threaten cell function and viability. A cellular event prone to disruption by a wide variety of internal and external perturbations is protein folding. To ensure protein folding can proceed under a range of conditions, the cell has evolved transcriptional, translational, and posttranslational signaling pat...
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Probably the most important message that a Forum on the reduction–oxidation (redox) environment in the endoplasmic reticulum (ER) must nowadays convey is that an ‘‘ER redox state’’ as such does not exist. The ER rather features a variety of redox systems, which—in many cases—react independently with incoming substrates and xenobiotics. Thus, any statement claiming ER hyperor hypo-oxidation unde...
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Laboratory of Molecular and Cellular Biology, Department of Molecular Biosciences, Faculty of Life Sciences, Kyoto Sangyo University, Kyoto 603-8555, Japan; Institute for Protein Dynamics, Kyoto Sangyo University, Kyoto 603-8555, Japan; Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Saitama 332-0012, Japan; Laboratory for Developmental Neurobi...
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Calcium ion (Ca2+) is an important second messenger that regulates numerous cellular functions. Intracellular Ca2+ concentration ([Ca2+]i) is strictly controlled by Ca2+ channels and pumps on the endoplasmic reticulum (ER) and plasma membranes. The ER calcium pump, sarco/endoplasmic reticulum calcium ATPase (SERCA), imports Ca2+ from the cytosol into the ER in an ATPase activity-dependent manne...
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Soil salinity is a crucial environmental constraint which limits biomass production at many sites on a global scale. Saline growth conditions cause osmotic and ionic imbalances, oxidative stress and perturb metabolism, e.g., the photosynthetic electron flow. The plant ability to tolerate salinity is determined by multiple biochemical and physiological mechanisms protecting cell functions, in pa...
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ژورنال
عنوان ژورنال: Cold Spring Harbor Perspectives in Biology
سال: 2018
ISSN: 1943-0264
DOI: 10.1101/cshperspect.a033910